تعیین ارتباط بین وابستگی به مورفین و تغییرات هیستوپاتولوژیک مغزی در موش صحرایی

  Opium Dependency and Histopathologic Changes of Brain in Rat     R. Malekpour Afshar [1] , R. Seyfaddini [2] , E. Koohpayehzadeh Esfahani [3] , N. Nakhaee [4] , T. Eslammanesh [5]     Received: 19/10/09 Sent for Revision: 25/02/10 Received Revised Manuscript: 12/06/10 Accepted: 03/07/10     Background and Objectives: Central nervous system is one of the primary targets of the detrimental effects of narcotics. Although opiates are among the most drugs of abuse, little is known about their side effects on the brain structures. Most investigations in this field are about their biochemical or psychological side effects. In this study pathologic changes in morphine dependent rats have been investigated.   Materials and Methods: In this experimental study, 48 male wistar rats were divided into 6 groups. The dependent groups received 0.4mg/ml morphine in drinking water for 7, 28 and 56 days. The control groups received a solution of saccharose in drinking water for the same periods and then the histological studies of the brain samples were done.   Results: Significant neuronal loss in frontal and parietal lobes and hippocampus was observed. Results also showed a significant relationship between the duration of morphine intake and neuronal loss.   Conclusion: The results of this study, in line with the other studies in this field indicate that opiate drugs might induce neuronal damage after long term exposure. These changes could be more significant in chronic addiction. Since brain atrophy is the most common pathology in dementia, further investigations for finding probable relations between dementia and opiate dependency is suggested.   Key words: Dependency, Central nervous system, Histopathology, Morphine, Rat     Funding: This research was funded by Kerman Neuroscience Research Center (KNRC).   Conflict of Interest: None declared.   Ethical Approval: The Ethics Committee of Kerman University of Medical Sciences approved the study.     [1] - Associate Prof., Dept. of Pathology, Neuroscience Research Center, University of Medical Sciences, Kerman, Iran   [2] - Assistant Prof., Dept. of Neurology, University of Medical Sciences, Kerman, Iran   [3] - General Practitioner, University of Medical Sciences, Kerman, Iran   [4] - Associate Prof., Dept. of Social Medicine, University of Medical Sciences, Kerman, Iran   [5] - Pathologist, University of Medical Sciences, Kerman,Iran  Corresponding autor , Tel : (0341) 2233600, Fax:(0341) 2232600 , E-mail: [email protected]